Dysplastic nevus - Dysplastyske Nevus
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Dysplastic nevi ― Biopsie wurdt oanrikkemandearre foar westerlingen.
References
Dysplastic nevus , ek wol bekend as in atypyske of Clarks nevus, hat debatten yn dermatology en dermatopathology opsmiten. Dokters faak biopsy dizze mollen omdat se kinne sjen abnormaal en meitsje soargen oer melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , ek bekend as atypysk of Clark nevi, kin soms liede ta melanoma. Ungefear 36% fan melanomen wurde fûn tichtby dysplastyske nevi. Skaaimerken dat in dysplastyske nevus kin feroarje yn melanoma omfetsje unjildige foarm, mear pigmentferoarings, of in griisige kleur. Dizze kankers komme normaal foar op in jongere leeftyd (om 'e midden fan 'e tritiger jierren) , kinne meardere wêze, en binne faak op 'e romp. Genetysk binne dysplastic nevi tusken goedaardige nevi en melanoma. Mar mar 20% oant 30% fan melanomen komme fan besteande nevi. Om't de measte nevi gjin melanoma wurde, wurdt it normaal net oan te rieden om se previntyf te ferwiderjen.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
In melanoma is in soarte fan tumor dy't ûntstiet as melanozyten, sellen ferantwurdlik foar hûdkleur, kanker wurde. Melanozyten ûntsteane út 'e neural crest. Dit betsjut dat melanomen net allinich op 'e hûd kinne ûntwikkelje, mar ek yn oare gebieten wêr't neuronale krystsellen migrearje, lykas it gastrointestinale traktaat en harsens. It oerlibjensnivo foar pasjinten mei melanoma yn 'e iere faze (stadium 0) is heech op 97%, wylst it signifikant sakket nei sawat 10% foar dyjingen dy't diagnostearre binne mei sykte yn in avansearre stadium (stadium IV) .
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Kankerrisiko
Lykas sjoen yn Kaukasyske persoanen yn 'e Feriene Steaten, hawwe dy mei dysplastyske nevi in libbensrisiko fan it ûntwikkeljen fan melanoma fan grutter dan 10%. Oan 'e oare kant hawwe dejingen sûnder dysplastyske nevus in risiko op it ûntwikkeljen fan melanoma fan minder dan 1%.
○ Foarsoarch foar persoanen mei dysplastyske nevi
Hûd selsûndersyk wurdt meastentiids oanrikkemandearre foar it foarkommen fan melanoma (troch it identifisearjen fan atypyske nevi dy't kinne wurde fuortsmiten) of foar iere opspoaren fan besteande tumors. Minsken mei in persoanlike of famyljeskiednis fan hûdkanker of fan meardere atypyske nevi moatte op syn minst ien kear yn 't jier in dermatolooch sjen om der wis fan te wêzen dat se gjin melanoma ûntwikkelje.
De ôfkoarting [ABCDE] is nuttich west om sûnenssoarchferlieners en leken te helpen by it ûnthâlden fan de wichtichste skaaimerken fan in melanoma. Spitigernôch foar de trochsneed persoan, in protte seborrheic keratoses, guon lentigo senilis, en sels wratten kinne hawwe [ABCDE] skaaimerken, en kin net wurde ûnderskieden fan in melanoma.
○ [ABCDE]
Asymmetrical: Asymmetryske hûdlesion.
Border: De grins fan 'e lesion is ûnregelmjittich.
Color: melanomen hawwe meastentiids meardere unregelmjittige kleuren.
Diameter: nevi grutter as 6 mm binne earder melanomen as lytsere nevi.
Evolution: De evolúsje (d.w.s. feroaring) fan in nevus of lesion kin oanjaan dat de lesion malignant wurdt.